Depletion Magnitude

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Marty Hinz MD Medical Foods™

Medical Food For the management of hyposerotonergic™ conditions

Application #1: The management of SSRI-induced serotonin depletion™

Drugs that work with neurotransmitters do not work if there are not enough neurotransmitters.™

The only way to increase the synthesis of the total number of serotonin molecules in the central nervous system is by administering the required nutrients.™

Platelets contain 99% of whole blood serotonin1

Medical science literature documents the magnitude of SSRI-induced serotonin depletion:

  • SSRIs may deplete 80% of platelet serotonin in two weeks2
  • SSRIs may deplete 90% of platelet serotonin in three weeks3
  • Eventually lab assay of platelet serotonin may become undetectable4

Click Here – SSRI Induced Serotonin Depletion Brochure

1McCloskey, D. et al. Selective Serotonin Reuptake Inhibitors (SSRIs): Measurement of Effect on Platelet Function Transl Res. 2008 March ; 151(3): 168–172
2Jordan, S. et al. Serotonergic agents increase the incidence of GI bleeds in patients with continuous-flow left ventricular assist devices J heart and lung tplt 05 Jan 2016, 35(6):823-824
3Wagner, A. et. al. Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder, J of Affective Disorders, 20 (1990) 101-113
4Mauer-Spurej E. et al. The influence of selective serotonin reuptake inhibitors on human platelet serotonin Thromb Haemost 2004;91:119-28