SSRI-induced Part 1

Application #1: The management of
SSRI-induced serotonin depletion™

Drugs that work with neurotransmitters do not work if there are not enough neurotransmitters.™

The only way to increase the synthesis of the total number of serotonin molecules in the central nervous system is by administering the required nutrients.™

SSRI-induced serotonin depletion™

Part 1

When SSRI-induced serotonin depletion occurs, serotonin depletion symptoms™ may develop, and serotonin-dependent mechanisms of action™ may be compromised or cease to function.

NIH definition, mechanism of action: In medicine, a term used to describe how a drug or other substance produces an effect in the body.
NIH National Cancer Institute website: Link to NIH Site

R&R™ specially formulated for the management of
SSRI-induced serotonin depletion™,
the dietary management of which cannot be achieved
by the modification of the normal diet alone.

What is wrong with this statement? “SSRIs rapidly increase the amount of serotonin in the brain.”

ANSWER: SSRIs do nothing to increase the amount (number of molecules) of serotonin in the brain. The opposite is true; SSRIs can deplete over 90% of the serotonin in the body within three weeks. Then after longer periods of taking SSRIs system serotonin can become so low that it is undetectable with lab testing.

Illustrations courtesy National Institute of
Drug Abuse division National Institute of Health

SSRI Depletion Figure 1

Figure 1: Low synaptic serotonin concentrations

Figure 1: Low synaptic serotonin levels induced by SSRIs on a modified normal diet represent a hyposerotonergic condition where there is inadequate serotonin binding to the post-synaptic receptors.